Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Ophthalmol. May 12, 2015; 5(2): 36-44
Published online May 12, 2015. doi: 10.5318/wjo.v5.i2.36
Corneal transplantation: Beyond the horizon
Kelvin Ho-Nam Wan, Evan Po-Fat Yiu, Alvin L Young
Kelvin Ho-Nam Wan, Evan Po-Fat Yiu, Department of Ophthalmology, Tuen Mun Eye Centre and Tuen Mun Hospital, Hong Kong, China
Alvin L Young, Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital and Alice Ho Liu Ling Nethersole Hospital, Hong Kong, China
Kelvin Ho-Nam Wan, Alvin L Young, Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong, China
Author contributions: Young AL studied and designed the conception; Wan KHN and Young AL acquainted of data; Wan KHN analyzed and interpreted the data; and drafted of manuscript; Wan KHN, Yiu EPF and Young AL made the critical revision.
Conflict-of-interest: No conflicting relationship exists for any author.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alvin L Young, MMedSc, FRCS, Chief, Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China. youngla@ha.org.hk
Telephone: +852-2-6322878 Fax: +852-2-6482943
Received: November 17, 2014
Peer-review started: November 18, 2014
First decision: January 20, 2015
Revised: March 4, 2015
Accepted: March 30, 2015
Article in press: April 2, 2015
Published online: May 12, 2015

Evolving techniques in keratoplasty have undoubtedly led to thinner corneal grafts. These newer iterations of keratoplasty aim to reduce graft rejections, improve visual acuity and visual rehabilitation. Each technique poses its own advantages and disadvantages; the surgeon should select patients suitable for a particular technique while accounting for their surgical competency given the learning curve associated with these newer techniques. Alternatives to corneal transplant may have a role in addressing the shortages of corneal graft, these bioengineered material and medical treatment still need further studies to demonstrate its clinical applicability.

Keywords: Cornea, Cell therapy, Keratoplasty, Bullous keratopathy, Techniques

Core tip: Review of the current status of corneal transplant, the issues encountered with current techniques, the potential and future treatment on the horizon.