Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Ophthalmol. Feb 12, 2015; 5(1): 31-35
Published online Feb 12, 2015. doi: 10.5318/wjo.v5.i1.31
Recent advances in management of retinoblastoma: A review
Bhavna Chawla, Gautam Lokdarshi, Sushmita Pathy
Bhavna Chawla, Gautam Lokdarshi, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India
Sushmita Pathy, Department of Radiotherapy, IRCH, All India Institute of Medical Sciences, New Delhi 110029, India
Author contributions: Chawla B contributed to the conception and design, literature search, writing the article, critical revision of the article; Lokdarshi G and Pathy S contributed to writing the article, literature search; all authors final approval of the article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Bhavna Chawla, MS, Additional Professor, Ocular Oncology and Pediatric Ophthalmology Service, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
Telephone: +91-11-26593088 Fax: +91-11-26588919
Received: July 11, 2014
Peer-review started: July 12, 2014
First decision: September 28, 2014
Revised: October 27, 2014
Accepted: October 31, 2014
Article in press: November 3, 2014
Published online: February 12, 2015

The management of retinoblastoma has evolved significantly over recent years. Current treatment options aim to preserve the globe as well as vision with minimum morbidity. High resolution imaging has improved tumor detection and is useful for prognosticating cases and monitoring response to treatment. Targeted chemotherapy such as intra-arterial and intra-vitreal chemotherapy has shown promising results and these routes are being increasingly employed world-wide for globe preservation. The advent of new radiotherapy techniques has led to improved radiation delivery to the target and more conformal treatment plans with better normal tissue sparing. This review aims to highlight newer advancements in the field of diagnosis and management of retinoblastoma that have been introduced in recent times, with a special emphasis on globe-preserving therapy.

Keywords: Retinoblastoma, Recent advances, Chemotherapy, Radiotherapy

Core tip: The management of retinoblastoma has improved significantly over the past few decades. There has been a paradigm shift from enucleation towards conservative treatment modalities that aim at vision and globe salvage. The purpose of this article is to review the literature on various key developments in the field of retinoblastoma, with particular emphasis on globe-conserving treatment.