Published online Feb 12, 2015. doi: 10.5318/wjo.v5.i1.31
Peer-review started: July 12, 2014
First decision: September 28, 2014
Revised: October 27, 2014
Accepted: October 31, 2014
Article in press: November 3, 2014
Published online: February 12, 2015
The management of retinoblastoma has evolved significantly over recent years. Current treatment options aim to preserve the globe as well as vision with minimum morbidity. High resolution imaging has improved tumor detection and is useful for prognosticating cases and monitoring response to treatment. Targeted chemotherapy such as intra-arterial and intra-vitreal chemotherapy has shown promising results and these routes are being increasingly employed world-wide for globe preservation. The advent of new radiotherapy techniques has led to improved radiation delivery to the target and more conformal treatment plans with better normal tissue sparing. This review aims to highlight newer advancements in the field of diagnosis and management of retinoblastoma that have been introduced in recent times, with a special emphasis on globe-preserving therapy.
Core tip: The management of retinoblastoma has improved significantly over the past few decades. There has been a paradigm shift from enucleation towards conservative treatment modalities that aim at vision and globe salvage. The purpose of this article is to review the literature on various key developments in the field of retinoblastoma, with particular emphasis on globe-conserving treatment.