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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Obstet Gynecol. May 10, 2015; 4(2): 40-45
Published online May 10, 2015. doi: 10.5317/wjog.v4.i2.40
Published online May 10, 2015. doi: 10.5317/wjog.v4.i2.40
Effect of the maternal-fetal interface immunoregulation on the occurrence of intrahepatic cholestasis of pregnancy
Xiu Quan Zhang, Michael L Draper, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT 84132, United States
Li-Juan Zhang, Wei-Hong Yang, Department of Obstetrics and Gynecology, Xiangya Second Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Zhang XQ, Zhang LJ, Yang WH and Draper ML contributed to this paper.
Conflict-of-interest: Authors have no conflict of interest for this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiu Quan Zhang, MD, PhD, Department of Obstetrics and Gynecology, University of Utah School of Medicine, 50 N Medical Dr., Salt Lake City, UT 84132, United States. xiuquan.zhang@hsc.utah.edu
Telephone: +1-801-5813117 Fax: +1-801-5858552
Received: October 27, 2014
Peer-review started: October 27, 2014
First decision: December 12, 2014
Revised: January 14, 2015
Accepted: January 30, 2015
Article in press: February 2, 2015
Published online: May 10, 2015
Peer-review started: October 27, 2014
First decision: December 12, 2014
Revised: January 14, 2015
Accepted: January 30, 2015
Article in press: February 2, 2015
Published online: May 10, 2015
Core Tip
Core tip: In this paper, we reviewed the recent publications regarding the role of immunological interactions at the maternal-fetal interface on the occurrence of intrahepatic cholestasis. The literature shows that the decidual immunological microenvironment may relate to the development of intrahepatic cholestasis of pregnancy. Any approach that modulates immune tolerance at the maternal-fetal interface toward the natural state could provide insight in the treatment of intrahepatic cholestasis of pregnancy.