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World J Obstet Gynecol. May 10, 2014; 3(2): 78-84
Published online May 10, 2014. doi: 10.5317/wjog.v3.i2.78
Published online May 10, 2014. doi: 10.5317/wjog.v3.i2.78
Fetal lung surfactant and development alterations in intrahepatic cholestasis of pregnancy
Yi-Ling Ding, Li-Juan Zhang, Xin Wang, Na Li, Chang-Xiu Wang, Department of Obstetrics and Gynecology, Xiangya Second Hospital, Central South University, Changsha 410011, Hunan Province, China
Qi-Chang Zhou, Ultrasonography, Department of Radiology, Xiangya Second Hospital, Central South University, Changsha 410011, Hunan Province, China
Xiu-Quan Zhang, Department of Obstetrics and Gynecology and Reproductive Genetics, University of Utah School of Medicine, Salt Lake City, UT 84132, United States
Author contributions: Ding YL and Zhang LJ contributed equally to this work; Zhang LJ and Ding YL developed the conception and designed the study; Wang X, Li N and Wang CX collected and analyzed the data; Zhou QC conducted the ultrasonography; Zhang LJ and Zhang XQ drafted the manuscript and interpreted the data; Zhang XQ revised and final approved the manuscript.
Correspondence to: Xiu-Quan Zhang, MD, Department of Obstetrics and Gynecology and Reproductive Genetics, University of Utah School of Medicine, 50 North Medical. Drive, Salt Lake City, UT 84132, United States. xiuquan.zhang@hsc.utah.edu
Telephone: +1-801-5853117 Fax: +1-801-5813552
Received: June 28, 2013
Revised: November 21, 2013
Accepted: January 13, 2014
Published online: May 10, 2014
Revised: November 21, 2013
Accepted: January 13, 2014
Published online: May 10, 2014
Core Tip
Core tip: We studied total bile acid (TBA) concentration in maternal, fetal and amniotic fluid and its relationship with fetal surfactant, surfactant protein A, amniotic lamellar body and fetal lung development. Results demonstrated that intrahepatic cholestasis of pregnancy (ICP) has higher TBA in maternal and fetal blood and amniotic fluid. The high concentration of TBA may affect fetal pulmonary surfactant production and fetal lung maturation. It calls attention to delayed maturation of fetal lungs in ICP patients and to take steps to carefully check and improve fetal pulmonary maturity.