Case Control Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Obstet Gynecol. Feb 10, 2015; 4(1): 9-15
Published online Feb 10, 2015. doi: 10.5317/wjog.v4.i1.9
High prevalence of post-partum depression in women with coeliac disease
Raffaella Tortora, Nicola Imperatore, Carolina Ciacci, Fabiana Zingone, Pietro Capone, Monica Siniscalchi, Lucienne Pellegrini, Giuliano De Stefano, Nicola Caporaso, Antonio Rispo
Raffaella Tortora, Nicola Imperatore, Pietro Capone, Giuliano De Stefano, Nicola Caporaso, Antonio Rispo, Gastroenterology, Department of Clinical Medicine and Surgery, University “Federico II of Naples”, 80131 Napoli, Italy
Carolina Ciacci, Fabiana Zingone, Monica Siniscalchi, Lucienne Pellegrini, Department of Gastroenterology, University of Salerno, 84084 Fisciano Salerno, Italy
Author contributions: Tortora R and Capone P drafted the article; Imperatore N substantially contributed to conception and design of the work; Ciacci C and Caporaso N finally approved the version to be published; Zingone F revised the article critically for important intellectual content; Siniscalchi M contributed to psychological evaluation and acquisition of data for the work; Pellegrini L acquired the data for the work; De Stefano G analyzed the data for the work; Rispo A analysed and interpreted the data for the work, drafted the article or revised it critically for intellectual content.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Raffaella Tortora, MD, Gastroenterology, Department of Clinical Medicine and Surgery, University “Federico II of Naples”, Via S. Pansini 5, 80131 Napoli, Italy. raffaellatortora@live.com
Telephone: +39-817-464270 Fax: +39-817-464270
Received: June 19, 2014
Peer-review started: June 20, 2014
First decision: July 21, 2014
Revised: October 14, 2014
Accepted: October 29, 2014
Article in press: October 29, 2014
Published online: February 10, 2015
Abstract

AIM: To explore the prevalence of post-partum depression (PPD) in coeliac disease (CD).

METHODS: We performed a case-control study evaluating the prevalence of PPD in CD patients on gluten-free diet (GFD) compared to that of healthy subjects experiencing a recent delivery. All participants were interviewed about menstrual features, modality and outcome of delivery and were evaluated for PPD by Edinburgh Postnatal Depression Scale (EPDS).

RESULTS: The study included 70 CD patients on GFD (group A) and 70 controls (group B). PPD was present in 47.1% of CD women and in 14.3% of controls (P < 0.01; OR = 3.3). Mean EPDS score was higher in CD compared to the controls (mean score: group A 9.9 ± 5.9; group B 6.7 ± 3.7; P < 0.01). A significant association was observed between PPD and menstrual disorders in CD (69.7% vs 18.9%; P < 0.001; OR = 3.6).

CONCLUSION: PPD is frequent in CD women on GFD, particularly in those with previous menstrual disorders. We suggest screening for PPD in CD for early detection and treatment of this condition.

Keywords: Coeliac disease, Depression, Post-partum depression, Menstrual disorders, Gluten-free diet

Core tip: Some studies have shown an increased prevalence of psychological symptoms and mental disorders in patients affected by coeliac disease (CD) and depression appears to be the most important condition in undiagnosed CD. On the other hands, focused data on post-partum depression are still lacking. In our mind, the present work is the first study mainly focused on this interesting and relevant topic.