Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Mechanical transduction by ion channels: A cautionary tale
Frederick Sachs, UB School of Medicine and Biomedical Sciences, Physiology and Biophysics, Buffalo, NY 14214, United States
Author contributions: Sachs F oversaw all the research and wrote this paper, but was assisted by an enormous number of collaborators and students who are referenced in the bibliography.
Supported by NIH R01HL054887.
Conflict-of-interest statement: The author declares that there is no conflict of interest.
Open-Access: This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Frederick Sachs, PhD, UB School of Medicine and Biomedical Sciences, Physiology and Biophysics, 301 Cary Hall, Buffalo, NY 14214, United States. sachs@buffalo.edu
Telephone: +1-716-8295161 Fax: +1-716-8292569
Received: July 10, 2014
Peer-review started: July 10, 2014
First decision: August 14, 2014
Revised: June 11, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: September 28, 2015
Peer-review started: July 10, 2014
First decision: August 14, 2014
Revised: June 11, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: September 28, 2015
Core Tip
Core tip: Mechanosensitive ion channels are found in all cells and their physiological function in most cells has yet to be defined inviting new researchers to the field. This review provides some guidelines to help newcomers understand key issues and potential artifacts.