Systematic Reviews
Copyright ©The Author(s) 2022.
World J Hematol. Jul 29, 2022; 9(3): 20-29
Published online Jul 29, 2022. doi: 10.5315/wjh.v9.i3.20
Table 1 Comparative table of the studied articles
Type of study
Main results
Dham et al[15], 2009WashingtonCase control364Children with SCA have a mild increase in SCA, which correlates with increased cardiac output and left ventricular filling pressures
Cuervo et al[22], 2002CubaCase control53Restrictive ventilatory dysfunction was observed in all patients with sickle cell anemia
Fitzhugh et al[19], 2010North CarolinaRetrospective transversal240This study points out the main causes of death in patients with SCA. Among them are: Pulmonary emboli, stroke and multiple organ failure. In addition, it mentions the main pre-morbid conditions found: Pneumonia, congestive heart failure, myocardial infarction and arrhythmias
Parent et al[13], 2011FranceTransversal398Patients with confirmed pulmonary hypertension were older and had worse functional capacity than other patients
Damy et al[32], 2016FranceTransversal 1.780TRV ≥ 2.5 m/s and left ventricular dysfunction predict mortality in patients with SCA
Arteta et al[27], 2014MichiganCohort146It is common for children with sickle cell anemia to have abnormal lung function, most often of the obstructive type
Lobo et al[18], 2015Rio de JaneiroProspective transversal125Patients over 32-years-old have mostly elevated LDH, severe anemia and creatinine clearance > 1, in addition to a poor prognosis, and may be at risk of developing pulmonary hypertension