Systematic Reviews
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World J Hematol. Jul 29, 2022; 9(3): 20-29
Published online Jul 29, 2022. doi: 10.5315/wjh.v9.i3.20
Cardiopulmonary changes in patients with sickle cell anemia: A systematic review
Jamile Silva Lopes, Ícaro Garcia Viana, Maria Luísa Cordeiro Santos, Fabrício Freire de Melo, Márcio Vasconcelos Oliveira, Cláudio Lima Souza
Jamile Silva Lopes, Ícaro Garcia Viana, Maria Luísa Cordeiro Santos, Fabrício Freire de Melo, Márcio Vasconcelos Oliveira, Cláudio Lima Souza, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
Author contributions: All authors contributed equally to this paper with conception and design of the study, literature review and analysis, drafting and critical revision, editing and final approval of the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, PhD, Adjunct Professor, Instituto Multidisplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Vitória da Conquista 45029-094, Bahia, Brazil. freiremelo@yahoo.com.br
Received: August 30, 2021
Peer-review started: August 30, 2021
First decision: December 2, 2021
Revised: December 13, 2021
Accepted: July 8, 2022
Article in press: July 8, 2022
Published online: July 29, 2022
Core Tip

Core Tip: Sickle cell anemia (SCA) is the most common and severe form of sickle cell disease (SCD) accounting for approximately 70% of SCD cases worldwide. Illness related to SCA is an important public health problem as it is a serious chronic disease with limited possibility of cure and that causes suffering to its patients. With adult age and aging, cardiopulmonary changes are mainly observed. Given their high prevalence and the clinical impact caused to patients with SCA, this study compiled information about cardiopulmonary changes in patients with SCA.