Granulysin and its clinical significance as a biomarker of immune response and NK cell related neoplasms

Table 1 Saposin-like protein family members and their proposed functions

Family member	Function	Identity to 9-kDa granulysin (amino acid)1	Similarity to 9-kDa granulysin (amino acid)2
Saposin A	Sphingolipid hydrolase activator	21	46
Saposin B	Sphingolipid hydrolase activator	19	50
Saposin C	Sphingolipid hydrolase activator	19	53
Saposin D	Sphingolipid hydrolase activator	20	46
Pulmonary surfactant protein B	Lipid organization in pulmonary surfactant	19	53
Acyloxyacyl hydrolase	Phagocytic cell lipase	22	50
Acyloxyacyl hydrolase	Sphingolipid hydrolase	13	42
Amoebapore A	Pore-forming Entamoeba histolytica granule protein	16	47
Amoebapore B	Pore-forming Entamoeba histolytica granule protein	13	42
Amoebapore C	Pore-forming Entamoeba histolytica granule protein	18	47
NK-lysin	Lytic porcine T cell and NK cell granule protein	35	66
Granulysin	Lytic human T cell and NK cell granule protein	100	100

¹Identity denotes the percentage of identical amino acids;

²Similarity denotes amino acids that share chemical properties, for example, charge or hydrophobicity. NK: Natural killer.