Published online Nov 6, 2014. doi: 10.5315/wjh.v3.i4.128
Revised: February 18, 2014
Accepted: February 20, 2014
Published online: November 6, 2014
Core tip: Granulysin is a cytotoxic granular protein expressed in cytotoxic T cells, natural killer (NK) cells and γδT cells, and has anti-microbial activity against microorganisms such as bacteria, fungi, mycobacteria and parasites, as well as tumoricidal activity against some tumors. It is secreted constitutively and in a trigger-dependent manner. Clinically, serum granulysin is a unique biomarker for immune response, immune capacity and NK cell related neoplasms.