Copyright ©The Author(s) 2017.
World J Hematol. Aug 6, 2017; 6(3): 32-54
Published online Aug 6, 2017. doi: 10.5315/wjh.v6.i3.32
Figure 11
Figure 11 Results of treatment in 13 patients with primary or essential thrombocythemia and 13 patients with polycythemia vera and thrombocythemia. Source Michiels et al[53], 1985. Busulfan induced remission of thrombocythemia (platelet counts < 350 × 109/L) lasted 2 to 9 years (long busulfan remitters) in essential thrombocythemia (ET) patients, which became asymptomatic with no recurrence of erythromelalgia after discontinuation of aspirin during thrombocythemia remission periods of 2 to 9 years (R). Erythromelalgia recurred in eight [5 ET, 3 polycythemia vera (PV)] of twelve (8ET, 4PV) at platelet counts between 400 to 550 × 109/L (P) after thrombocythemia remission periods of 2 to 8 years. Busulfan induced remissions of thrombocythemia in the majority of PV patients lasted several months to a few years (short buslfan remittors) indicating the need to treat with repeated courses of busulfan.