Published online Aug 6, 2017. doi: 10.5315/wjh.v6.i3.32
Peer-review started: March 24, 2017
First decision: April 18, 2017
Revised: July 3, 2017
Accepted: July 17, 2017
Article in press: July 17, 2017
Published online: August 6, 2017
Core tip: About seventy years after the synthesis by Hoffmann, acetyl salicylic acid (aspirin) has been discovered in the late 1970s as a wunder drug that cures erythromelalgia and migraine-like cerebral microvascular disturbances by irreversible blockage of platelet cyclo-oxygenase mediated arteriolar inflammation and thrombosis in JAK2-mutated thrombocythemia of patients with essential thrombocythemia (ET) and polycythemia vera (PV). The ADP (P2Y12) receptor inhibtors ticlopedin and clopidogrel, other platelet inhibitors that do not affect platelet cycooxygenase, and coumarin are ineffective in the treatment of erythromelalgia and cerebral vascular thrombotic complications in ET and PV.