Basic Study
Copyright ©The Author(s) 2016.
World J Hematol. Nov 6, 2016; 5(4): 75-87
Published online Nov 6, 2016. doi: 10.5315/wjh.v5.i4.75
Table 3 Transcriptional factors, protein name and their description or function
TFProtein nameTF description/function
ARAndrogen receptorThe protein functions as a steroid-hormone activated transcription factor
Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. They are expressed in bone marrow, mammary gland, prostate, testicular and muscle tissues where they exist as dimers coupled to Hsp90 and HMGB proteins
ARID3AAT rich interactive domain 3A (BRIGHT-like)This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins
ARNTAryl hydrocarbon receptor nuclear translocatorInvolved in the induction of several enzymes that participate in xenobiotic metabolism
ARNT:AHRHypoxia-inducible factor 1:Aryl hydrocarbonThe dimer alters transcription of target genes. Involved in the induction
receptor nuclear translocatorof several enzymes that participate in xenobiotic metabolism
ATF7Activating Transcription Factor 7Plays important functions in early cell signaling
Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers
ATOH1Atonal homolog 1Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47
BATF::JUNBasic leucine zipper transcription factor, ATF-like Jun proto-oncogeneThe protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events
BRCA1Breast cancer 1, early onsetThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor
CEBPACCAAT/enhancer binding protein, alphaCCAAT/enhancer binding protein is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers
CREB1cAMP responsive element binding protein 1Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element, a sequence present in many viral and cellular promoters
CRXCone-rod homeoboxThe protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function
CTCFCCCTC-binding factor (zinc finger protein)This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger domains. This nuclear protein is able to use different combinations of the zinc finger domains to bind different DNA target sequences and proteins
E2F1-6E2F transcription factors 1-6The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins, a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain
EBF1Transcription factor COE1EBF1 has been shown to interact with ZNF423 and CREB binding proteins
EGR1Early growth response 1The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis
EGR2Early growth response 2The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers
Sequence-specific DNA-binding transcription factor
EHFEts homologous factorThis gene encodes a protein that belongs to an erythroblast transformation-specific transcription factor subfamily characterized by epithelial-specific expression. The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis
ELF1E74-like factor 1 (ets domain transcription factor)The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes
ELF5E74-like factor 5A member of an epithelium-specific subclass of the Ets Transcription factor family
ELK1ELK1, member of ETS oncogene familyThis gene is a member of the Ets family of transcription factors and of the ternary complex factor subfamily. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade
ELK4ELK4, ETS-domain protein (SRF accessory protein 1)This gene is a member of the Ets family of transcription factors and of the ternary complex factor subfamily. Proteins of the ternary complex factor subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene
EN1Engrailed homeobox 1Homeobox-containing genes are thought to have a role in controlling development
ERGv-ets avian erythroblastosis virus E26 oncogene homologThis gene encodes a member of the erythroblast transformation-specific family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis
ESR2Estrogen receptor betaEstrogen receptor β is a member of the family of estrogen receptors and the superfamily of nuclear receptor transcription factors and is expressed by many tissues including blood monocytes and tissue macrophages, colonic and pulmonary epithelial cells
ESRRAEstrogen-related receptor alphaThis nuclear receptor acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase and thyroid hormone receptor genes
ETS1Protein C-ets-1The protein encoded by this gene belongs to the erythroblast transformation-specific family of transcription factors and has been shown to interact with TTRAP, UBE2I and Death associated protein
FEVETS oncogene familyIt functions as a transcriptional repressor
FLI1Fli-1 proto-oncogene, ETS transcription factorSequence-specific transcriptional activator
FOSFBJ murine osteosarcoma viral oncogene homologThe Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death
FOSL1 and 2FOS-like antigen 1 and 2GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity
FOXA1Forkhead box A1Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a "pioneer" factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites
Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate. Modulates the transcriptional activity of nuclear hormone receptors
FOXA2Forkhead box A2Involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues
FOXC1Forkhead box C1An important regulator of cell viability and resistance to oxidative stress in the eye
FOXL1Forkhead box L1Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog signaling pathway
FOXO1Forkhead Box O1Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress
FOXO3Forkhead Box O3This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death
FOXP1Forkhead box P1This gene belongs to subfamily P of the forkhead box transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium
FOXQ1Forkhead box Q1This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. Plays a role in hair follicle differentiation
GABPAGA-binding protein alpha chainOne of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit which shares identity with a subunit encoding the nuclear respiratory factor 2 gene and is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function
GATA1GATA binding protein 1The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin
GATA2GATA binding protein 2A member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes and play an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages
GATA3GATA binding protein 3Plays an important role in endothelial cell biology
GFIGrowth factor independent 1 transcription repressorThis gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters
GMEB2Glucocorticoid modulatory element binding protein 1This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication
HAND1:TCFE2αHeart- and neural-crest derivatives-expressed protein 1: Transcription factor E2AHand1 belongs to the basic helix-loop-helix family of transcription factors
The Tcfe2a gene encodes the transcription factor E2A, a member of the “class I” a family of basic helix-loop-helix transcription factors (also known simply as "E-proteins"). The transcription factor E2A controls the initiation of B lymphopoiesis
HIC1Hypermethylated in cancer 1This gene functions as a growth regulatory and tumor repressor gene
HIF1A:ARNT HLTFHypoxia-inducible factor 1: Aryl hydrocarbon receptor nuclear translocator Helicase-like transcription factorHIF1 is a homodimeric basic helix-loop-helix structure composed of HIF1a, the alpha subunit, and the aryl hydrocarbon receptor nuclear translocator (Arnt), the beta subunit. The protein encoded by HIF1 is a Per-Arnt-Sim transcription factor found in mammalian cells growing at low oxygen concentrations. It plays an essential role in cellular and systemic responses to hypoxia Member of the SWItch/Sucrose Non Fermentable family which have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin
HNF1AHepatocyte nuclear factor 1 homeobox ATranscriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver
HNF1BHNF1 homeobox BThis gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas
HNF4αHepatocyte nuclear factor 4, alphaThe protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines
HNF4γHepatocyte nuclear factor 4, gammaSteroid hormone receptor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RXRA
HOXA5Homeobox protein Hox-A5DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation
ISNM1Insulinoma-associated 1Insulinoma-associated 1 gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors
IRF1,2Interferon regulatory factorMembers of the interferon regulatory transcription factor family that contain a conserved
N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the interferon consensus sequence
JDP2Jun dimerization protein 2Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris
JUNJun Proto-OncogeneThis gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression
JUNDJun D proto-oncogeneThe protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis
JUN::FOSJun proto-oncogene FBJ murine osteosarcoma viral oncogene homologPromotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation
KLF1Kruppel-like factor 1 (erythroid)Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching
KLF4Krueppel-like factor 4Transcription factor that can act both as activator and as repressor. Regulates the expression of key transcription factors during embryonic development
KLF5Krueppel-like factor 5This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants
MAXMYC associated factor XThe protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper family of transcription factors
MAFKv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog KSince they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites
MEF2AMyocyte enhancer factor 2AThe protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival
MGAMGA, MAX Dimerization ProteinFunctions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator
MYBMyb proto-oncogene proteinThis gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. Transcriptional activator and plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells
MYCv-myc myelocytomatosis viral oncogene homologThe protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix domain. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas
MZF1_1-4Myeloid zinc finger 1Binds to target promoter DNA and functions as transcription regulator. May be one regulator of transcriptional events during hemopoietic development. Isoforms of this protein have been shown to exist at protein level
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex
NFIANuclear Factor I/ARecognizes and binds the palindromic sequence 5-TTGGCNNNNNGCCAA-3 present in viral and cellular promoters transcription and replication and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
NFICNuclear factor 1 C-typeRecognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
NFE2::MAFNuclear factor, erythroid 2 V-maf avian musculoaponeurotic fibrosarcoma oncogene homologRegulates erythroid and megakaryocytic maturation and differentiation. Plays a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. When overexpressed, represses anti-oxidant response element-mediated transcription
NFE2L1:MAFGNuclear factor erythroid 2-related factor 1 Transcription factor MafGNuclear factor erythroid 2-related factor coordinates the up-regulation of cytoprotective genes via the antioxidant response element. MafG is a ubiquitously expressed small maf protein that is involved in cell differentiation of erythrocytes. It dimerizes with P45 NF-E2 protein and activates expression of a and b-globin
NFIL3Nuclear factor, interleukin 3 regulatedExpression of interleukin-3 (MIM 147740) is restricted to activated T cells, natural killer cells, and mast cell lines
NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1natural killer-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis
NFYBNuclear transcription factor Y, betaThe protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif
NHLH1Nescient helix loop helix 1The helix-loop-helix proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species
NKX2-5Natural killer 3 homeobox 2This gene encodes a member of the NK family of homeobox-containing proteins
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation
NKX3-2Natural killer 3 homeobox 2This gene encodes a member of the NK family of homeobox-containing proteins Transcriptional repressor that acts as a negative regulator of chondrocyte maturation
NR1H3:RXRaNuclear Receptor Subfamily 1, Group H, Member 3 Retinoid X receptor, alphaThe protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor, and regulates expression of target genes containing retinoid response elements Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis
NR2C2Nuclear receptor subfamily 2, group C, member 2Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways
NR2E3Nuclear receptor subfamily 2, group E, member 3This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways
NR2F1 (COUP)Nuclear receptor subfamily 2, group F, member 1Binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. An important paralog of this gene is RXRA
NR3C1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Glucocorticoids regulate carbohydrate, protein and fat metabolism, modulate immune responses through suppression of chemokine and cytokine production and have critical roles in constitutive activity of the CNS, digestive, hematopoietic, renal and reproductive systems
NR4A2Nuclear receptor subfamily 4, group A, member 2Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic neurons during development
NRF1Nuclear respiratory factor 1This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication
NRLNeural Retina Leucine ZipperThis gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function
PAX2Paired box gene 2Probable transcription factor that may have a role in kidney cell differentiation
PDX1Pancreatic and duodenal homeobox 1Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription
PPARγ:RXRαPeroxisome proliferator-activated receptor gamma Retinoid X receptor, alphaPeroxisome proliferator-activated receptor gamma is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with the retinoic X receptor to regulate gene expression. Peroxisome proliferator-activated receptor gamma is located primarily in the adipose tissue, lymphoid tissue, colon, liver and heart and is thought to regulate adipocyte differentiation and glucose homeostasis
RXRaRetinoid X receptor, alphaRetinoid X receptors and retinoic acid receptors, are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation
RFX5Regulatory factor X, 5Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and natural killer-Y. Regulatory factor X binds the X1 box of MHC-II promoters
RUNX1Runt-related transcription factor 1Heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of core binding factor and is thought to be involved in the development of normal hematopoiesis
SOX6SRY (sex determining region Y)-box 6The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells
SOX9SRY (sex determining region Y)-box 9The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the involved in chondrogenesis by acting as a transcription factor for these genes
SOX10SRY (sex determining region Y)-box 10This gene encodes a member of the SRY-related HMG-box family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate
SOX17SRY (sex determining region Y)-box 17Acts as transcription regulator that binds target promoter DNA and bends the DNA
SP1Specificity Protein 1Can activate or repress transcription in response to physiological and pathological stimuli. Regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses
SP2Specificity Protein 2This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters
SPIBTranscription factor Spi-BSPI1 and SPIB are members of a subfamily of erythroblast transformation-specific transcription factors; erythroblast transformation-specific proteins share a conserved erythroblast transformation-specific domain that mediates specific DNA binding SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-)
SPI1Spleen focus forming virus proviral integration oncogene spi1This gene encodes an erythroblast transformation-specific-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development
SPZ1This gene encodes a basic helix-loop-helix-zip transcription factor which functions in the mitogen-activate protein kinase signaling pathway
SRYSex determining region YTranscriptional regulator that controls a genetic switch in male development
STAT3Signal transducer and activator of transcription 3 (acute-phase response factor)Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors
STAT5A:STAT5BSignal transducer and activator of transcription 5A and transcription 5BCarries out a dual function: signal transduction and activation of transcription Regulates the expression of milk proteins during lactation
TCF7L2Transcription factor 7-like 2 (T-cell specific, HMG-box)This gene encodes a high mobility group box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis
TEAD1TEA Domain Family Member 1This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor
TFAP2aActivator protein 2The AP2a protein acts as a sequence specific DNA-binding transcription factor recognizing and binding to the specific DNA sequence and recruiting transcription machinery
THAP1THAP domain containing, apoptosis associated protein 1DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression
USF1Upstream transcription factor 1This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs
YY1YY1 transcription factorYY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1
ZEB1Zinc finger E-box-binding homeobox 1A member of the delta-EF1 (TCF8)/Zfh1 family of 2-handed zinc finger/homeodomain proteins and interacts SMADs with receptor-mediated, activated full-length activated full-length SMADs
ZNF263Zinc finger protein 263Might play an important role in basic cellular processes as a transcriptional repressor. An important paralog to ZNF496
ZNF354CZinc finger protein 354CMay function as a transcription repressor