Published online Nov 6, 2016. doi: 10.5315/wjh.v5.i4.75
Peer-review started: May 9, 2016
First decision: June 13, 2016
Revised: June 24, 2016
Accepted: August 11, 2016
Article in press: August 13, 2016
Published online: November 6, 2016
Core tip: Disease or trait-predisposing single nucleotide polymorphisms (SNPs) in or near genes can alter the transcriptional factor binding sites (TFBS) for the TFs regulating the gene; thereby affecting the health of an individual. In this report, the disease or sickness associated regulatory SNPs (rSNPs) within a sampling of nine human genes were studied with respect to the alterations in TFBS. From this sampling there were 73 punitive unique TFBS generated by the common rSNP alleles compared to 124 generated by the minor alleles indicating the tremendous diversity of potential TFs that are capable of affecting the health of person.