Copyright ©The Author(s) 2016.
World J Hematol. May 6, 2016; 5(2): 51-60
Published online May 6, 2016. doi: 10.5315/wjh.v5.i2.51
Figure 2
Figure 2 Key mediators of angiogenesis in multiple myeloma and their regulation by miRNAs. Pro-angiogenic factors are subject to regulation by hypoxia that triggers hypoxia-induce factor 1α, and by other signals (e.g., TGFβ, TNFα), and are fine-tuned by different microRNAs. Green arrows, increased expression levels; red arrows, decreased expression levels. RECK: Reversion-inducing-cysteine-rich protein with kazal motifs; MMP: Matrix metalloproteinase; FIH-1: Factor inhibiting HIF-1; HIF-1α: Hypoxia-inducible factor 1-alpha; VEGF: Vascular endothelial growth factor; bFGF: Basic fibroblast growth factor.