Published online May 6, 2016. doi: 10.5315/wjh.v5.i2.51
Peer-review started: August 13, 2015
First decision: November 6, 2015
Revised: November 19, 2015
Accepted: January 21, 2016
Article in press: January 22, 2016
Published online: May 6, 2016
Core tip: The pathogenesis of multiple myeloma (MM) requires that malignant cells remain viable and proliferate. Therefore, genes relating to the regulation of apoptosis, proliferation and angiogenesis are tightly regulated. Specifically, angiogenesis, which is driven by the interactions between the malignant cells and stroma cell surrounding them, is critical for MM progression. In this review we summarize the current knowledge about the regulation of the expression of genes related to apoptosis, proliferation and angiogenesis, through the activity of specific microRNAs.