Role of microRNA in regulation of myeloma-related angiogenesis and survival

Figure 1 Cell-cell interactions that mediate angiogenesis (in a hypoxic microenvironment). Interactions between multiple myeloma plasma cells, endothelial cells and different myeloid cells (including infiltrating monocytes, immature myeloid cells such as myeloid-derived suppressor cells, and osteoclasts) stimulate secretion of pro-angiogenic factors. MMP: Matrix metalloproteinase; MM: Multiple myeloma; IL: Interleukin; I-TAC: Interferon-inducible T-cell alpha chemoattractant; SDF-1: Stromal cell-derived factor 1; IGF: Insulin-like growth factor; TGFβ: Transforming growth factor beta; VEGF: Vascular endothelial growth factor; bFGF: Basic fibroblast growth factor.