Copyright ©The Author(s) 2016.
World J Hematol. May 6, 2016; 5(2): 51-60
Published online May 6, 2016. doi: 10.5315/wjh.v5.i2.51
Table 2 Involvement of microRNAs in the regulation of multiple myeloma-related angiogenesis
Target increasedTarget reducedEffect (anti-angiogenic)Effect (pro-angiogenic)Ref.
miRNA reduced
miR-15a, miR-16, miR-145VEGF, ERK pathway, AKT pathwayReduced EC growth, reduced ability to form capillary structures[30,31,48]
miR-199a-5pHIF-1α, SIRT-1Increased expression of VEGF, IL-8, bFGF, CXCL12, MMP-2[47]
miRNA increased
Let 7 familyThrombospondin-1, TIMP-1Inhibiting anti-angiogenic factors[48]
miR-92-1Angiopoietin-like protein 1Inhibit anti-angiogenic protein[48]
miR-135bFIH-1Alleviate HIF-1α inhibition[45]