Role of microRNA in regulation of myeloma-related angiogenesis and survival

Table 2 Involvement of microRNAs in the regulation of multiple myeloma-related angiogenesis

	Target increased	Target reduced	Effect (anti-angiogenic)	Effect (pro-angiogenic)	Ref.
miRNA reduced
miR-15a, miR-16, miR-145	VEGF, ERK pathway, AKT pathway		Reduced EC growth, reduced ability to form capillary structures		[30,31,48]
miR-199a-5p	HIF-1α, SIRT-1		Increased expression of VEGF, IL-8, bFGF, CXCL12, MMP-2		[47]
miRNA increased
Let 7 family		Thrombospondin-1, TIMP-1		Inhibiting anti-angiogenic factors	[48]
miR-92-1		Angiopoietin-like protein 1		Inhibit anti-angiogenic protein	[48]
miR-135b		FIH-1		Alleviate HIF-1α inhibition	[45]

VEGF: Vascular endotelial growth factor; ERK: Extracellular signal-regulated kinase; HIF-1α: Hypoxia inducible factor 1 alpha; SIRT-1: Sirtuin 1; FIH-1: Factor inhibiting HIF-1; IL-8: Interleukin-8; bFGF: Basic fibroblast growth factor; MMP: Matrix metalloproteinase.