Copyright ©The Author(s) 2016.
World J Hematol. May 6, 2016; 5(2): 51-60
Published online May 6, 2016. doi: 10.5315/wjh.v5.i2.51
Table 1 Involvement of microRNAs in multiple myeloma cell proliferation and apoptosis
ActivatormiRNA reducedmiRNA overexpressedTarget increasedTarget decreasedEffectRef.
Deletion, othermiR-15a, miR-16AKT, S6, MAPK, MAP3KIP3 (TAB3)Increased proliferation and survival[30]
miR-30-5p familyBCL9Increased Wnt/β-catenin activation[32]
c-Myc (reduced)miR-17/92 clusterBimIncreased apoptosis[36,40]
Sp-1 (increased)miR-29bSp-1, CDK6, Mcl-1, caspase-3, Rb phosphorylation[41,42]
miR-34a, miR-192, miR-194, miR-215MDM2, IGF-1Cell proliferation[34]
miR-19a/bSOCS1, BimReduced apoptosis[36]
miR-181a/b, miR-32PCAFReduced p53 acetylation[36]
miR-221, miR-222P27Kip1, p57Kip2, PUMA, PTENIncreased proliferation[35]