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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: A case report
Qian Gao, You-Peng Jin, Pediatric Intensive Care Unit, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong Province, China
Xiao-Wei Xin, Chun Zhao, Yu-Juan Wang, Wei Wang, Yi Yin, Xiao-Ru Wang, You-Peng Jin, Pediatric Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Author contributions: Material preparation and data collection were performed by Jin YP and Gao Q; the first draft of the manuscript was written by Gao Q; all authors read and approved the final manuscript; all authors contributed to the case report conception and design.
Supported by Clinical Science and Technology Innovation Scheme of Jinan Province , No. 202019177 and No. 201704071 .
Informed consent statement: Informed written consent was obtained from the patient’ parents for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: You-Peng Jin, PhD, Chief Doctor, Pediatric Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China. jinyp79@sina.cn
Received: September 29, 2021
Peer-review started: September 29, 2021
First decision: December 2, 2021
Revised: December 9, 2021
Accepted: February 12, 2022
Article in press: February 12, 2022
Published online: February 25, 2022
Peer-review started: September 29, 2021
First decision: December 2, 2021
Revised: December 9, 2021
Accepted: February 12, 2022
Article in press: February 12, 2022
Published online: February 25, 2022
Core Tip
Core Tip: Hemophagocytic hymphohistiocytosis (HLH) is an often fatal disease. We report an 11-year-old female who was diagnosed with Epstein-Barr virus-HLH and presented with coagulation disorders, liver damage, and respiratory insufficiency. In the present case, initially elevated interleukin (IL)-6, IL-8, IL-10, and interferon-γ levels were reduced to within normal ranges following hemoadsorption with HA330-II, and the patient’s condition gradually improved. HA330-II hemoadsorption has the ability to bridge the patient until chemotherapy can contribute to reduced HLH disease activity.