Published online Aug 6, 2013. doi: 10.5315/wjh.v2.i3.62
Revised: May 14, 2013
Accepted: June 8, 2013
Published online: August 6, 2013
Core tip: Towards the end of the nineteenth century, a clearer definition of the classification of leukemia had been established leading to different subtypes. These well-defined subtypes of leukemia were used for the development of effective chemotherapy, which has represented the most important advance in leukemia research during the past half century.