Published online May 6, 2013. doi: 10.5315/wjh.v2.i2.6
Revised: March 29, 2013
Accepted: April 10, 2013
Published online: May 6, 2013
Core tip: Recently manufactured assays allow the quantification of serum immunoglobulin (Ig) free light chain (sFLC) or of κ or λ restricted heavy Ig chain separately (HLC). These measurements, or the calculation of their corresponding ratios, were shown useful for routine clinical practice in Hematology. sFLC measurements added important prognostic information for monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM), amyloid light-chain (AL) amyloidosis, Waldenstrom’s macroglobulinemia and chronic lymphocytic leukemia while they contributed to accurate follow-up of MGUS, MM and AL amyloidosis patients. HLC measurements are more recent and mainly concern MM in which they constituted a prognostic marker.