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©2013 Baishideng. All rights reserved.
Emerging immunological concepts in the pathogenesis of myelodysplastic syndromes
Claudio Fozza, Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Author contributions: Fozza C ideated and wrote the manuscript.
Correspondence to: Claudio Fozza, MD, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 12, 07100 Sassari, Italy. cfozza@uniss.it
Telephone: +39-79-228282 Fax: +39-79-228282
Received: January 15, 2013
Revised: February 9, 2013
Accepted: March 23, 2013
Published online: May 6, 2013
Revised: February 9, 2013
Accepted: March 23, 2013
Published online: May 6, 2013
Core Tip
Core tip: T-lymphocytes are deeply involved in the pathogenesis of myelodysplastic syndromes (MDS); patients with MDS display a typical T-cell repertoire pattern; specific T-cell subsets, such as regulatory T-cells and Th17 T-cells, play a specific riole in in this context.