Published online Nov 12, 2018. doi: 10.5315/wjh.v7.i1.1
Peer-review started: July 2, 2018
First decision: August 9, 2018
Revised: September 14, 2018
Accepted: November 2, 2018
Article in press: November 2, 2018
Published online: November 12, 2018
Platelets are responsible for blood haemostasis. Although anucleate, a complete translational machinery has been found in platelets, which is responsible for new protein generation. Recently, the role of miRNAs in platelets has started to become apparent. In this editorial I highlight this topic in the hope that other scientists may be attracted to work in this area to aid a more complete understanding of protein regulation in platelets and its impact on platelet function.
Core tip: miRNAs have been recently identified as a mechanism for regulating protein content in several cell types including platelets. In fact, certain miRNAs have been recently associated with some platelet-related pathologies. Moreover, changes in the miRNAs expression profiles have been evidenced in platelet activated by certain agonists. So, future researches will be needed to provide more information regarding platelet miRNAs in order to be used as an alternative therapy to the nowadays antiplatelet drugs.