Clinical pharmacokinetics profile of ivermectin 1% cream after dermal applications on the face

Figure 1 Plasma concentration-time curves after application of ivermectin 1% cream in healthy volunteers (means). QD: Once a day; BID: Twice a day.

Figure 2 Plasma concentration-time curves after application of ivermectin 1% cream once a day in subject with severe papulopustular rosacea.

Figure 3 Mean AUC_{0-24 h} of ivermectin and its circulating major metabolites versus study days in subject with severe papulopustular rosacea. AUC_{0-24 h}: Area under the plasma concentration-time curve from pre-application (T0) through to 24 h.

Figure 4 Individual ivermectin plasma profiles in a semi-logarthmic scale. (A: Study #1; B: Study #2) in subject with severe papulopustular rosacea.