Published online Aug 2, 2014. doi: 10.5314/wjd.v3.i3.64
Revised: May 28, 2014
Accepted: June 27, 2014
Published online: August 2, 2014
Core tip: Skh-1 hairless mice were given 4 daily 20 μL aliquots of different concentrations of d-limonene, and then irradiated to a single ultraviolet irradiation. Skin samples from the ultraviolet-exposed area of mice showed that ultraviolet irradiation induced cyclobutane pyrimidine dimers formation, N-myc downstream regulating gene 1 and proliferating cell nuclear antigen expression, pretreatment of d-limonene significantly reduced these responses. Pure d-limonene also induced the expression of epidermal barrier protein filaggrin. In conclusion, d-limonene protected the mice skin from UV-induced DNA photodamage and sunburn in mice skin.