Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives

doi:10.5312/wjo.v5.i4.496

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 5, Issue 4

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6631)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-1) series.

Item

Count

PDF

377

WORD

266

HTML

3116

Tables (1-1)

131

Sum=3890

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1237

Download

1504

Sum=2741

Sep 18, 2014 (publication date) through Apr 16, 2024

Times Cited of This Article

Times Cited (9)

Journal Information of This Article

Publication Name

World Journal of Orthopedics

ISSN

2218-5836

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Topic Highlight

World J Orthop. Sep 18, 2014; 5(4): 496-503
Published online Sep 18, 2014. doi: 10.5312/wjo.v5.i4.496

Table 1 Janus kinase small molecule inhibitors in development

SMI	JAK Specificity/other kinase inhibitory activity	Ref.
SAR302503 (Fedratinib)	JAK2	[46]
CEP701 (Lestaurtinib)	JAK2	[47]
SB1518 (Pacritinib)	JAK2/FLT3¹	[48]
XL-019	JAK2	[48]
LY2784544	JAK2/V617F²	[49,50]
AZD1480	JAK2	[51]
NS-108	JAK2/Src³	[52]
BMS-911453	JAK2	[53]

¹FLT3: Fms-like tyrosine kinase 3; a receptor-type tyrosine-protein kinase;

²V617F: A point mutation in JAK2 (V617F) identified in the hematopoietic cells of patients with several chronic myeloproliferative disorders;

³Src: V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; JAK: Janus kinase; SMI: Small molecule inhibitor.

Citation: Malemud CJ, Blumenthal DE. Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives. World J Orthop 2014; 5(4): 496-503
URL: https://www.wjgnet.com/2218-5836/full/v5/i4/496.htm
DOI: https://dx.doi.org/10.5312/wjo.v5.i4.496