Copyright ©The Author(s) 2017.
World J Orthop. Sep 18, 2017; 8(9): 674-680
Published online Sep 18, 2017. doi: 10.5312/wjo.v8.i9.674
Table 1 Summary of studies using mesenchymal stem cells for cartilage regeneration in osteoarthritis
Ref.Type of studyType of cellsSignificance
Wakitani et al[33]Case and control studyAutologous BMSCs from Iliac crestAutologous BMSCs cell implants are effective for treating OA cartilage defects in humans, producing hyaline like cartilage
Centeno et al[26]Case studyAutologous BMSCs from Iliac crestAutologous BMSCs can be introduced by intra-articular injections into an osteoarthritic knee promotes cartilage regeneration and reduction pain
Buda et al[23]Case seriesAutologous BMSCs from Iliac crestOne-step repair technique utilising bone-marrow concentrate is a simple and time-efficient way to treat large chondral defects
Koh et al[34]Case and control studyAutologous AMSCs from infrapatellar fat padIntra-articular injections of AMSCs are a safe treatment option, reducing pain and improving the function of knee OA patients
Wong et al[28]Randomized control trialAutologous BMSCs from Iliac crestPostoperative intra-articular injections of autologous BMSCs improves the MOCART outcomes of patients with varus knees undergoing HTO and microfracture
Vangsness et al[30]Randomized, double-blind, controlled studyAllogenic BMSCs from 18-30 years old donorsPostoperative intra-articular injections of allogenic BMSCs contribute to meniscus regeneration and reduction in pain following medial meniscectomy
Jo et al[29]Cohort studyAutologous AMSCs from abdominal subcutaneous fatsCartilage regeneration and pain reduction is significantly improved when high amounts of AMSCs are injected into OA knees compared with low amounts
Sekiya et al[35]Therapeutic studyAutologous synovial MSCsLocalized synovial MSCs can be used to treat cartilage defects resulting in hyaline like cartilage and improved pain scores