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Copyright ©2014 Baishideng Publishing Group Co.
World J Clin Oncol. May 10, 2014; 5(2): 48-60
Published online May 10, 2014. doi: 10.5306/wjco.v5.i2.48
Table 1 List of major oncogenic microRNAs in breast cancer
MiRNAKnown target mRNAFunctionRef.
MiR-10bHOXD10Promotes cell proliferation, metastasis and angiogenesis[108]
MiR-126IGFBP2, MERTK, PITPNC1Promotes angiogenesis[18]
MiR-155SOCS1, TP53INP1, FOXO3, RhoAPromotes cell proliferation[12,20,21,62]
MiR-21PTEN, TPM1, PDCD4, MaspinPromotes cell proliferation[22-24,109]
MiR-375RASD1Epigenetic modification of tumor suppressor genes[110,111]
MiR-221/222TRPS1Induce metastasis[28,29,65]
MiR-373CD-44Induce metastasis[14,26]
MiR-520cCD-44Induce metastasis[14,26]
MiR-9SOCS5, E-cadherinInduce metastasis[27,112,113]
MiR-632DNAJB6Induce metastasis[30]
MiR-196bHOXD10 (indirect)Promotes angiogenesis[15]
MiR-7HOXB3Epigenetic modification of tumor suppressor genes[16]
MiR-218HOXB3Epigenetic modification of tumor suppressor genes[16]
MiR-203SOCS3Promotes cell proliferation[25]
Table 2 List of major tumor suppressor microRNAs in breast cancer
MiRNAKnown target mRNAFunctionRef.
Let-7 familyRAS, HMGA2Inhibit cell proliferation and mammosphere formation[11,114]
MiR-125HuR, HER2, ETS1, Cyclin J, MEGF9Inhibit cell proliferation and invasion[38,39,115,116]
MiR-205ZEB1 and ZEB2Reduces EMT and metastasis[1,40]
MiR-200 familyZEB1/2Reduces EMT and metastasis[117]
MiR-206Cyclin D2Inhibits Cyclin D2 in MCF-7 cells[118]
MiR-34aBcl2, SIRT1Inhibits migration, invasion and metastasis[69]
MiR-335SOX-4, TNCInhibits metastasis[41,42]
MiR-342HER2Increases cell proliferation[119]
MiR-15a/16HER2Increases cell proliferation[68]
MiR-302RAD52 and AKT1Affects DNA repair[78]
MiR-31RhoA, ITGA5, RDXReduces invasion and metastasis[44]
MiR-519cHIF-1αInhibits angiogenesis[45]