Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas

Table 1 Clinical characteristics of colorectal cancer patients included in the study, n (%)

Characteristics	Total (n = 223)	MMR-D/MSI-H (n = 87) (39.01%)	MMR-P/MSS (n = 136) (60.99%)	P value
Age				0.207
≤ 40 years	35 (15.7)	17 (19.5)	18 (13.2)
> 40 years	188 (84.3)	70 (80.5)	118 (86.8)
Sex				0.243
Male	146 (65.5)	61 (70.1)	85 (62.5)
Female	77 (34.5)	26 (29.9)	51 (37.5)
Location				< 0.001
Right	130 (58.3)	69 (79.3)	61 (44.9)
Left	93 (41.7)	18 (20.7)	75 (55.1)
Stage				< 0.001
I	14 (6.2)	6 (6.9)	8 (5.9)
II	126 (56.5)	67 (77)	59 (43.4)
III	83 (37.2)	14 (16.1)	69 (50.7)
Overall survival at five years	-	92%	71%	< 0.001

MMR-D: Mismatch repair deficient; MSI-H: Microsatellite instability-high; MMR-P: Mismatch repair proficient; MSS: Microsatellite stable.

Table 2 Pathological characteristics of colorectal cancer patients included in the study, n (%)

Characteristics	Total (n = 223)	MMR-D/MSI-H (n = 87) (39.01%)	MMR-P/MSS (n = 136) (60.99%)	P value
Morphology				0.092
Adenocarcinoma	181 (81.1)	72 (82.8)	109 (80.1)
Mucinous adenocarcinoma	26 (11.7)	13 (14.9)	13 (9.6)
Signet ring carcinoma	12 (5.4)	1 (1.1)	11 (8.1)
Others	4 (1.8)	1 (1.1)	3 (2.2)
Grade				0.708
Well-differentiated	2 (0.9)	1 (1.1)	1 (0.7)
Moderately differentiated	167 (74.9)	63 (72.4)	105 (77.2)
Poorly differentiated	53 (23.8)	23 (26.4)	30 (22.1)
Mucinous component				0.078
≤ 50%	204 (91.5)	76 (87.4)	128 (94.1)
> 50%	19 (8.5)	11 (12.6)	8 (5.9)
Lymphovascular invasion				< 0.001
Absent	131 (58.7)	66 (75.9)	65 (47.8)
Present	92 (41.3)	21 (24.1)	71 (52.2)
Perineural invasion				< 0.001
Absent	188 (84.3)	83 (95.4)	105 (77.2)
Present	35 (15.7)	4 (4.6)	31 (22.8)
Tumor budding				< 0.001
Low	76 (38.2)	43 (52.4)	33 (28.2)
Intermediate	26 (13.1)	12 (14.6)	14 (12)
High	97 (48.7)	27 (32.9)	70 (59.8)
Intraepithelial lymphocytes				< 0.001
None	113 (50.7)	19 (21.8)	94 (69.1)
Mild-moderate	42 (18.8)	17 (19.5)	25 (18.4)
Marked	68 (30.5)	51 (58.6)	17 (12.5)
Peritumoral lymphocytes				< 0.001
< 10%	89 (39.9)	21 (24.1)	68 (50)
10%-25%	96 (43)	43 (49.4)	53 (39)
25%-50%	31 (13.9)	17 (19.5)	14 (10.3)
> 50%	7 (3.1)	6 (6.9)	1 (0.7)
Lymph node yield, mean ± SD	25.96 ± 11.6	28.90 ± 12.80	23.95 ± 10.30	< 0.0001
Lymph node ratio, mean ± SD	0.09 ± 0.19	0.02 ± 0.05	0.14 ± 0.23	< 0.001

MMR-D: Mismatch repair deficient; MSI-H: Microsatellite instability-high; MMR-P: Mismatch repair proficient; MSS: Microsatellite stable.