Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 24, 2025; 16(6): 104243
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.104243
Phenotypic attributes and survival in mismatch repair deficient/microsatellite instability-high colorectal carcinomas
Anurag Mehta, Divya Bansal, Rupal Tripathi, Vidya Anoop
Anurag Mehta, Department of Laboratory Services, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, Delhi, India
Divya Bansal, Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, Delhi, India
Rupal Tripathi, Vidya Anoop, Department of Research, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, Delhi, India
Author contributions: Mehta A conceptualized the study; Bansal D, Tripathi R, and Anoop V performed the data curation; Mehta A and Bansal D performed the formal analysis and reviewed and edited the manuscript; Bansal D and Tripathi R prepared the original draft; and all authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Rajiv Gandhi Cancer Institute and Research Centre, approval No. Res/SCM/49/2021/160.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data is available with all the authors and can be provided on request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Divya Bansal, MD, Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini Sector 5, New Delhi 110085, Delhi, India. divyabansalrgci@gmail.com
Received: December 16, 2024
Revised: March 20, 2025
Accepted: May 7, 2025
Published online: June 24, 2025
Processing time: 188 Days and 3.5 Hours
Core Tip

Core Tip: Mismatch repair deficient/microsatellite instability-high (MMR-D/MSI-H) colorectal cancers (CRCs) account for 15% of CRCs exhibiting peculiar clinicopathological features. The correlation between MMR-D/MSI-H status and distinct lymph node characteristics, including increased lymph node yield, low lymph node ratio, and larger uninvolved node size, suggests a potential link to the heightened immune response typical of these cancers. These findings reinforce the promising prognosis associated with MMR-D/MSI-H CRC, reflecting improved overall survival rates compared to mismatch repair proficient or microsatellite stable tumors and offering valuable insights for tailored therapeutic approaches in this specific subtype of CRC.