Uveal melanoma: Recent advances in immunotherapy

Table 1 Drug therapies for metastatic uveal melanoma disease

Drug	Target	Action
Ipilimumab	CTLA-4	Blocking the CTLA-4 receptor, enhancing T-cell activation, amplifying T-cell-mediated immunity
Tremelimumab	CTLA-4	Blocking the CTLA-4 receptor, amplifying T-cell-mediated immunity
Nivolumab	PD-1	Activation of T cell-mediated response. Lysis and degradation of cancer cells
Pembrolizumab	PD-1	Activation of T cell-mediated response. Lysis and degradation of cancer cells
Coxsackievirus A21 (V937)		Augmented T-cell responses with consequent improved clinical activity
Lymphocyte-activation gene 3		Negatively regulation T-cell proliferation and effector T-cell function
Tebentafusp	T-cell-redirecting bispecific fusion proteins	Enhancing HLA-A*0201-restricted T-cell receptor specifically recognizing the glycoprotein 100

CTLA-4: Cytotoxic T-lymphocyte-associated protein 4; PD-1: Programmed cell death protein 1.