Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma

Table 1 Potential drugs identified using the Connectivity Map database

ID	Name	Score	Mechanism of action
BRD-K29733039	Deforolimus	−92.69	mTOR inhibitor
BRD-A48570745	Ivermectin	−91.74	GABA receptor regulator
BRD-K33583600	Isoliquiritigenin	−91.69	Guanylate cyclase activator
BRD-K59456551	Methotrexate	−90.69	Dihydrofolate reductase inhibitor
BRD-A43150328	Penicillic acid	−87.56	Another antibiotic
BRD-A64479082	Quinidine	−85.76	Sodium channel blocker
BRD-K35377380	I-OMe-AG-538	−83.43	IGF-1 inhibitor
BRD-K59570838	Homoveratrylamine	−82.67	Dopamine analog
BRD-A50675702	Fipronil	−80.55	GABA gated chloride channel blocker

mTOR: Mammalian target of rapamycin; GABA: Gamma-aminobutyric acid; IGF-1: Insulin-like growth factor-1.