Relationship between anal cancer recurrence and cigarette smoking

Table 1 Demographic data

Variable	Cigarette use			P value
	Never, n = 37	Former, n = 22	Current, n = 36
Age in yr,				0.011
mean ± SD	63.70 ± 13.80	66.50 ± 13.17	57.40 ± 7.82
Clinical stage group				0.066
1	5 (13.5)	4 (18.2)	8 (22.2)
2	14 (37.8)	9 (40.9)	18 (50.0)
3	14 (37.8)	9 (40.9)	8 (22.2)
4	4 (10.8)	0	2 (5.6)
Race				0.273
Black	2 (5.4)	0	4 (11.1)
White	35 (94.6)	22 (100)	32 (88.9)
Sex				0.078
Female	30 (81.1)	17 (77.3)	21 (58.3)
Male	7 (18.9)	5 (22.7)	15 (41.7)
Length of follow-up in d				0.759
mean ± SD	1195.10 ± 1135.96	1023.20 ± 855.35	1218.20 ± 986.20

Data are n (%). SD: Standard deviation.

Table 2 Outcome data by group

Variable	Cigarette use			P value
	Never, n = 37	Former, n = 22	Current, n = 36
Death	14 (37.8)	6 (27.3)	8 (22.2)	0.332
Non-response	14 (37.8)	9 (40.9)	14 (38.9)	0.973
Recurrence	0	4 (30.8)	5 (20.8)	0.009
Time to recurrence in d (median interquartile range)	NA	195.0 (159.0-351.0)	362.0 (214.5-1019.0)	0.413
Recurrence and non-response combined	14 (37.8)	13 (59.1)	18 (50.0)	0.264

NA: Not available.

Table 3 Mortality subgroup analysis

Feature	Cigarette use			P value
	Never	Former	Current
Mortality* subgroup	n = 14	n = 6	n = 8
Time to death in d, mean ± SD	598.30 ± 734.61	848.40 ± 756.83	393.80 ± 325.69	0.465
Non-responder subgroup	n = 14	n = 9	n = 14
Deaths in non-responders subgroup, n (%)	6 (42.9)	2 (22.2)	3 (21.4)	0.285

*Death. SD: Standard deviation.