Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jul 24, 2023; 14(7): 259-264
Published online Jul 24, 2023. doi: 10.5306/wjco.v14.i7.259
Relationship between anal cancer recurrence and cigarette smoking
Kevin R McMahon, Nicholas Gemma, McKenzie Clapp, Patricia Sanchez-Montejo, Joseph Dibello, Erica Laipply
Kevin R McMahon, Nicholas Gemma, McKenzie Clapp, Patricia Sanchez-Montejo, Joseph Dibello, Erica Laipply, Department of General Surgery, Summa Health System, Akron, OH 44304, United States
Author contributions: McMahon KR designed and performed the research and wrote the paper; Gemma N helped write and revise the report; Dibello J assisted with data curation and editing of the report; Clapp M assisted with data curation and editing the report; Sanchez-Montejo P assisted with data analysis and editing the report; Laipply E designed the research and supervised the report.
Institutional review board statement: The study was reviewed and approved by the Summa Health System Institutional Review Board (Approval No. 21176).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to inclusion in the cancer registry used in this review.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Data sharing statement: Statistical code and dataset available from the corresponding author at kevin.mcmahon88@outlook.com. Consent was not obtained, but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kevin R McMahon, MD, Doctor, Department of General Surgery, Summa Health System, 55 Arch Street, Akron, OH 44304, United States. mcmahonkr@summahealth.org
Received: February 23, 2023
Peer-review started: February 23, 2023
First decision: March 28, 2023
Revised: May 10, 2023
Accepted: June 13, 2023
Article in press: June 13, 2023
Published online: July 24, 2023
Core Tip

Core Tip: This retrospective review examined the impact of smoking on anal cancer treatment for 95 patients. Smoking status was associated with a significantly higher rate of anal cancer recurrence after standard treatment. There was not a significant association between smoking status and anal cancer treatment non-response or mortality. Further study is needed to determine if smoking cessation would alter the course of anal cancer or if adjunct therapy would be beneficial in patients with anal cancer and a smoking history.