Copyright ©The Author(s) 2022.
World J Clin Oncol. Mar 24, 2022; 13(3): 200-208
Published online Mar 24, 2022. doi: 10.5306/wjco.v13.i3.200
Table 1 Malignancies with increased risk, or not reported in studies of patients with celiac disease
Ref.Study designIncreased risk No increased risk
Eigner et al[40]Retrospective cohortEATL -
Small bowel adenocarcinoma
Freeman[38]Retrospective cohortLymphoma-
Small bowel carcinoma
Hypopharyngeal carcinoma
Grainge et al[39]CohortAll malignancies-
Non-Hodgkin’s lymphoma
Howdle et al[32]Survey Small bowel adenocarcinoma-
Small bowel lymphoma
van Gils et al[47]Case-controlT-cell lymphoma, predominantly EATL Other types of lymphomas
Small bowel adenocarcinomaGI carcinomas
Esophageal squamous cell carcinoma
Anderson et al[48]Retrospective cohortNon-Hodgkin's lymphoma (but not statistically significant)-
Green et al[41]National surveySmall bowel adenocarcinoma -
Non-Hodgkin’s lymphoma
Han et al[42]Meta-analysisAll malignancies Other GI cancers
Small intestinal cancers
Esophageal cancer
Ilus et al[43]Retrospective cohortNon-Hodgkin lymphoma Decreased risk of lung, pancreatic, bladder, renal and breast cancer
Small intestinal cancer
Colon cancer
Basal cell carcinoma of the skin
Kent et al[49]CohortPapillary thyroid cancer -
Lebwohl et al[50]Population-based setting-Cutaneous malignant melanoma
Volta et al[51]Cohort-Colon carcinoma
Table 2 Malignancies associated with celiac disease in case reports
Diagnosis of malignancies (age in years)
Ahluwalia et al[52]Burkitt-like lymphoma of colon (75)
Buess et al[53]EATL causing obstructive jaundice (54)
Cankurtaran et al[54]Plasma cell dyscrasia (65)
Cereda et al[55]1st patient: Burkitt lymphoma of the small bowel (5)
2nd patient: Ependymoma (4)
3rd patient: Ewing sarcoma (6)
Zunguo et al[56]Large B-cell lymphoma and enteropathy-type T-cell lymphoma (65)
Fallah et al[57]Adenocarcinoma of the small intestine (89)
Jafroodi et al[58]Hodgkin’s lymphoma (11)
Naderi et al[59]Two patients: germ cell tumor (3.5 and 5)
3rd patient: Wilm’s tumor (6)
4th patient: Acute lymphobolastic lymphoma (4.5)
5th patient: Astrocytoma (8)
Sahin et al[60]Intestinal adenocarcinoma (58)
Zullo et al[61]Intestinal adenocarcinoma (77)