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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Mar 24, 2022; 13(3): 200-208
Published online Mar 24, 2022. doi: 10.5306/wjco.v13.i3.200
Published online Mar 24, 2022. doi: 10.5306/wjco.v13.i3.200
Possible relationship between refractory celiac disease and malignancies
Kaan Demiroren, Department of Pediatric Gastroenterology, University of Health Sciences, Yuksek Ihtisas Teaching Hospital, Bursa 16000, Turkey
Author contributions: Demiroren K solely contributed to this manuscript.
Conflict-of-interest statement: The author declares that no conflicts of interest, financial or otherwise, exist related to this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kaan Demiroren, MD, Associate Professor, Department of Pediatric Gastroenterology, University of Health Sciences, Yuksek Ihtisas Teaching Hospital, Mimar Sinan, Yıldirim, Bursa 16000, Turkey. kaandemiroren@yahoo.com
Received: April 9, 2021
Peer-review started: April 9, 2021
First decision: July 29, 2021
Revised: August 16, 2021
Accepted: March 6, 2022
Article in press: March 6, 2022
Published online: March 24, 2022
Peer-review started: April 9, 2021
First decision: July 29, 2021
Revised: August 16, 2021
Accepted: March 6, 2022
Article in press: March 6, 2022
Published online: March 24, 2022
Core Tip
Core Tip: Malignancies are among the leading consequence of celiac disease (CeD), and intestinal lymphoma and adenocarcinomas in particular. Enteropathy-associated T-cell lymphoma type 1 has been shown to develop from refractory CeD type 2, while the association of CeD with other cancer types is controversial. Decades of reported studies suggest that a non-delayed diagnosis of CeD and strict adherence to a gluten-free diet significantly reduces the rate of cancer development associated with CeD.