CITED2 and the modulation of the hypoxic response in cancer

Table 1 Effects of CITED2 in different cancer

Cancer type	CITED2 effect	Biological context	Cellular effects	Interaction with HIF-1α	Ref.
Breast cancer	Overexpression	Cell lines (MCF-7; SKBR-3; MDA-MB-231; MDA-MB-468; NT2.5); primary tumor; mouse xenograft	Proliferation; migration; metastization; chemoresistance; reduced survival	Not involved	[64,65,67-69,71]
Colorectal cancer	Downregulation	Cell lines (RKO; SW480)	Migration; invasion	Not determined	[75]
Prostate cancer	Overexpression	Cell lines (LNCaP; VCaP; DU145; PC-3; C4-2B; 22RV1); primary tumor; mouse xenograft	Invasion; metastization	Not determined	[79]
Gastric cancer	Overexpression	Cell lines (MKN74; MKN28; 7901; AGS; SNU-1; SNU-5; NCI-N87; KATO-III; MNK7; MNK45); primary tumor; transgenic mice	Proliferation; cell cycle progression; clonogenicity; chemoresistance	Not determined	[82,83]
Hepatocellular carcinoma	Downregulation	Cell lines (LO2; Hep3B; HepG2; BEL7404; primary tumor	Proliferation; clonogenicity	Not determined	[87-90]
Acute myeloid leukemia	Overexpression	Primary cell cultures; cell lines (NB4; MOLM-13); transgenic mice	Cell survival; proliferation; increased quiescence of AML-LSC	Self-renewal of AML-LSC	[101,103,104]
Lung cancer	Upregulation	Cell lines (A549; H1975; CL1-0; CL1-5); primary tumor	Cell cycle progression; clonogenecity; reduced survival	Not determined	[110]

HIF: Hypoxia-inducible factor.