Basic Study
Copyright ©The Author(s) 2019.
World J Clin Oncol. Mar 24, 2019; 10(3): 136-148
Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.136
Table 1 Table of chi-square test of association between fibroblast growth factor receptor 4 genotype (Gly/Gly, Gly/Arg or Arg/Arg) and other pathological variables
Fibroblast growth factor receptor 4 genotype
P-value
Gly388Arg388n
SexFemale3612480.157
Male15284236
Age, mean (SD); sample size54.20 (10.47); (188)53.42 (10.46); (96)2840.55291
Survey outcomeAlive80441240.598
Dead10852160
Histological gradingHigh71451160.177
Moderate9546141
Low10111
No difference12416
Progression statusPositive92381300.135
Negative9658154
Recurrence statusNegative134601940.133
Positive543690
Tumor sizeT12120410.004
T2622991
T3482472
T4572380
Lymph NodesN06626920.507
N1442872
N2533083
N3251237
MetastasesM0182922740.673
M16410
Table 2 Genotypes in patients and controls of fibroblast growth factor receptor 4 and calculated probability of gene distribution in second rows n (%)
Fibroblast growth factor receptor 4 genotypesCancer cases (n = 284)Controls (n = 123)
Gly/Gly188 (66.2)55 (45)
0.650.47
Gly/Arg84 (29.6)60 (49)
0.30.42
Arg/Arg12 (4.2)8 (6)
0.030.09
Table 3 Table of chi-square test of association correlating fibroblast growth factor receptor 4 expression, lymph nodes and therapy
Fibroblast growth factor receptor 4 expression
lowhighnP-value
Lymph nodesN0, N1 and N24794599380.0001
N311758175
ChemotherapyNo4032696720.0001
Yes193248441
Table 4 Table of chi-square test of association between fibroblast growth factor receptor 4 genotypes (Gly/Gly and Gly/Arg or Arg/Arg), Lymph nodes, tumor stage, and recurrence status
Fibroblast growth factor receptor 4 genotype
Gly388Arg388nP-value
Positive lymph nodesN0, N1 and N26442959390.010
N3751792
Tumor stageT1 and T2491865770.0001
T3 and T4228226454
Recurrence status05742087820.0001
1145104249
Table 5 Results from Logistic regression of lymph node, tumor stage and recurrence status on fibroblast growth factor receptor 4 genotype (P < 0.0001)
Fibroblast growth factor receptor 4 genotypeCoeff.Std. Err.zP >|z|Odds ratio95% CI
Recurrence status0.4400.16931792.60.0094.370.1080489-0.7717629
positive lymph nodes1.9720.158595812.440.000114.431.661438-2.283122
Tumor stage-1,7210.2903174-5.930.00010.24-2.29047-1.152446
constant-1.8260.1234243-14.790.0001-2.067534-1.58372