Published online Oct 24, 2024. doi: 10.5306/wjco.v15.i10.1376
Revised: July 24, 2024
Accepted: August 26, 2024
Published online: October 24, 2024
Processing time: 87 Days and 18.3 Hours
Gut dysbiosis, a phenomenon in which the existing commensal microbiome cha
Core Tip: It is fascinating to note that the gut microbiota can be the basis for the repeated occurrence of gut pathologies such as colonic polyps. Elucidating the various mechanisms involved would provide greater insights into the problem of colonic polyps.
- Citation: Govindarajan KK. Dysbiosis and colonic adenoma: The lethal link? World J Clin Oncol 2024; 15(10): 1376-1378
- URL: https://www.wjgnet.com/2218-4333/full/v15/i10/1376.htm
- DOI: https://dx.doi.org/10.5306/wjco.v15.i10.1376
Research has taken a big leap in understanding the role of microbes in the health and wellness of individuals. Estimation of volatile organic compounds in the exhaled breath produced by the gut microbiota and excreted through the lungs can help in linking the microbiota to the underlying disease condition. This has paved the way for designing novel and innovative non-invasive screening techniques. In line with this rationale the faecal microbial marker testing is a newer addition to the existing diagnostic armamentarium of colorectal cancer screening[1,2].
Gut dysbiosis is a phenomenon of bacterial disproportion in the intestine, reflecting the alteration of the bacterial milieu in the intestine with an increase in potentially harmful facultative anaerobic bacteria replacing beneficial obligate anaerobic bacteria. It is well known that the dysbiosis is connected with local and or systemic inflammation. Whether dysbiosis triggered the event or the culmination of sequelae is subject to debate and is not clearly understood. Several consequences such as altered host immune response, increased bacterial virulence and altered post-surgical survival have been noted to result from dysbiosis[3].
The altered gut flora in dysbiosis leading to a changed host immune response can set the stage for systemic sepsis. This can also be the basis for frequent relapses in patients with Inflammatory Bowel disease. Over a period of time, the dysbiosis causing local alterations can be a forerunner in the altered cellular and molecular level signals that initiate and propagate gene mutations ultimately ending in polyps[4,5]. Studies have shown the increased presence of certain microbiota (Streptococcaceae, Lachnoclostridium, and Ralstonia) in association with polyps. When the normal gut microbiota are changed or lost, the equilibrium in the colonic microenvironment is de-stabilised to a significant extent, resulting in the increased propensity of the mucosa to develop abnormal outgrowths such as polyps which may subsequently pro
It is interesting to see how the evidence would unfold incriminating the dysbiosis and genetic mechanisms that cause recurrent colonic adenoma.
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