Targeted immunotherapy for non-small cell lung cancer

Figure 1 Interaction between T cells and antigen presenting cells or tumor cells. The quality and amplitude of T cells depends on the balance of the above costimulatory and inhibitory signals and ultimate orchestration of death of tumor cells. Agonists of costimulators or antagonist of inhibitors are the main topic of the study as described. MHC-Ag: Major histocompatibility complex antigen; TCR: T cell receptor; PD-1: Programmed death-1; PD-L1: Programmed death ligand 1; CTLA-4: Cytotoxic T lymphocyte antigen-4.