Plasma methylation markers for early colorectal cancer detection

Figure 1 Example of multiplex probe amplification assay. A: Graphic presentation of the amplification plot and melting curve showed that the signal was from BCAN; B: Graphic presentation of the amplification plot and melting curve showed that the signal was from BMP3; C: Graphic presentation of the amplification plot and melting curve showed that the signal was from BCAN plus BMP3.

Figure 2  Normalized methylation levels of eight candidate markers in paired colorectal cancer and paracancerous tissues.

Figure 3 Performance of the candidate markers in colorectal cancer detection. A: Sensitivity and specificity of the candidate markers in the training set; B: Receiver operating characteristic curve of the training and validation sets; C: Receiver operating characteristic curve of the three-group comparison in all samples.