Mutational profile of a Saudi patient with Familial adenomatous polyposis that progressed to colon cancer: A case report

Figure 1 Progression of adenoma to colon cancer. A: Tubular adenomas with low-grade dysplasia showing dysplastic epithelium with elongated and hyperchromatic nuclei and variable amounts of mucin. Note abrupt transition from normal (arrow) to dysplastic mucosa [hematoxylin and eosin (HE) × 20]; B: Tubular adenomas with high-grade dysplasia showing cribriform pattern, nuclear stratification through the whole thickness of the epithelium, prominent nucleoli, loss of cell polarity, marked pleomorphism and atypical mitosis (HE × 20); C: Tubulovillous adenoma exhibiting admixture of tubular and villous components (HE × 4); D: Moderately differentiated infiltrating adenocarcinoma throughout the wall of colon (HE × 10).