Case Control Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Nov 10, 2018; 9(7): 133-139
Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.133
Mismatch repair protein expression and intratumoral budding in rectal cancer are associated with an increased pathological complete response to preoperative chemoradiotherapy: A case-control study
Leonardo S Lino-Silva, Armando Gamboa-Domínguez, Diego Zúñiga-Tamayo, Rosa A Salcedo-Hernández, Lucely Cetina, David Cantú-de-León
Leonardo S Lino-Silva, Surgical Pathology, Instituto Nacional de Cancerología, Mexico City 14080, Mexico
Armando Gamboa-Domínguez, Diego Zúñiga-Tamayo, Surgical Pathology, Instituto Nacional de ciencias Médicas y Nutrición salvador Zubirán, Mexico City 14080, Mexico
Rosa A Salcedo-Hernández, David Cantú-de-León, Surgical Oncology, Instituto Nacional de Cancerología, Mexico City 14080, Mexico
Lucely Cetina, Medical Oncology, Instituto Nacional de Cancerología, Mexico City 14080, Mexico
Author contributions: Lino-Silva LS, Gamboa-Domínguez A and Zúñiga-Tamayo D contributed equally to this work; Salcedo-Hernández RA, Cetina L and Cantú-de-León D designed research, Lino-Silva LS, Gamboa-Domínguez A, Zúñiga-Tamayo D and Salcedo-Hernández RA wrote the paper.
Institutional review board statement: This work was authorized by the institutional review board of the National Cancer Institute of Mexico with the number REV/16/87.
Informed consent statement: A waiver form informed consent was provided due the retrospective nature of the study and data were collected from clinical files and pathology database.
Conflict-of-interest statement: The authors declared no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Leonardo S Lino-Silva, MSc, Academic Research, Doctor, Gastrointestinal Pathology Division, Instituto Nacional de Cancerología de México (Mexico’s National Cancer Institute), Av. San Fernando # 22, Sección XVI, Tlalpan, Mexico City 14080, Mexico. saul.lino.sil@gmail.com
Telephone: +52-55-34265921
Received: July 6, 2018
Peer-review started: July 6, 2018
First decision: August 6, 2018
Revised: August 18, 2018
Accepted: October 24, 2018
Article in press: October 24, 2018
Published online: November 10, 2018
Core Tip

Core tip: Defective Mismatch repair (dMMR) and a low number of buds in the pretreatment biopsy were independently associated with a high rate of the pathological complete response. Tumor budding and MMR status should be considered as tools to be implemented in studies that predict the pathological response to preoperative chemo-radiotherapy in rectal cancer.