Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 10, 2016; 7(3): 293-301
Published online Jun 10, 2016. doi: 10.5306/wjco.v7.i3.293
Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging
Julie Veziant, Johan Gagnière, Elodie Jouberton, Virginie Bonnin, Pierre Sauvanet, Denis Pezet, Nicolas Barnich, Elisabeth Miot-Noirault, Mathilde Bonnet
Julie Veziant, Johan Gagnière, Virginie Bonnin, Pierre Sauvanet, Denis Pezet, Nicolas Barnich, Mathilde Bonnet, UMR1071 Inserm/Université d’Auvergne and INRA USC2018, Clermont Université, 63000 Clermont-Ferrand, France
Julie Veziant, Johan Gagnière, Pierre Sauvanet, Denis Pezet, Service de Chirurgie Digestive, Centre Hospitalier Universitaire, 63000 Clermont Ferrand, France
Elodie Jouberton, Elisabeth Miot-Noirault, UMR990 Inserm/Université d’Auvergne, Clermont Université, 63000 Clermont-Ferrand, France
Elodie Jouberton, Service de Médecine Nucléaire, Centre Jean Perrin, 63000 Clermont Ferrand, France
Author contributions: Veziant J, Gagnière J, Bonnet M conceived and designed the study, analyzed data and drafted the manuscript; Veziant J, Jouberton E, Bonnin V, Bonnet M performed experiments and analyses; Miot-Noirault E contributed to imaging platform management; Sauvanet P performed histological technics; Gagnière J, Pezet D, Barnich N, Miot-Noirault E and Bonnet M contributed to critical comments and revised the manuscript; all authors read, contributed to, and approved the final manuscript.
Supported by Veziant J was supported by «année-recherche» grants from the Ministère de la Santé and the Faculté de Médecine de Clermont-Ferrand; Gagnière J was supported by a “Nuovo Soldati Foundation for Cancer Research” grant.
Institutional review board statement: Not concerned.
Institutional animal care and use committee statement: The studies were performed in accordance with the French Regional Ethical Animal Use Committee (No. CEEA-02).
Conflict-of-interest statement: No.
Data sharing statement: Not concerned.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Mathilde Bonnet, PhD, UMR1071 Inserm/Université d’Auvergne and INRA USC2018, Clermont Université, 28 Place Henri Dunant, 63000 Clermont-Ferrand, France.
Telephone: +33-4-73178381 Fax: +33-4-73178381
Received: June 24, 2015
Peer-review started: June 28, 2015
First decision: October 8, 2015
Revised: February 29, 2016
Accepted: March 24, 2016
Article in press: March 25, 2016
Published online: June 10, 2016
Core Tip

Core tip: Approximately 15% of cancers are related to infectious agents. Colorectal cancer (CRC) is thus a complex association of non-neoplastic and tumoral cells and a large amount of microorganisms. Recent studies reported that pks-positive Escherichia coli (E. coli) strains are more frequently detected in CRC, suggesting their possible role in tumor development. Optical imaging has emerged as a powerful tool in translational cancer research, providing new possibilities for the spatiotemporal monitoring of carcinogenesis in mouse models. It may be particularly helpful in better understanding the in vivo host-pathogen-interactions in tumor development. This is the first study to use optical imaging to explore CRC carcinogenesis and associated pathogenic E. coli.