Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 10, 2015; 6(6): 272-280
Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.272
Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.272
Pelvic radiation disease: Updates on treatment options
Leonardo Frazzoni, Marina La Marca, Franco Bazzoli, Lorenzo Fuccio, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Alessandra Guido, Alessio Giuseppe Morganti, Division of Radiation Oncologym S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Author contributions: All the authors equally contributed to the paper and approved the current version of the article.
Conflict-of-interest statement: All the authors declare not to have any conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lorenzo Fuccio, MD, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. lorenzofuccio@gmail.com
Telephone: +39-51-2143338
Received: July 3, 2015
Peer-review started: July 5, 2015
First decision: July 31, 2015
Revised: September 18, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 10, 2015
Peer-review started: July 5, 2015
First decision: July 31, 2015
Revised: September 18, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 10, 2015
Core Tip
Core tip: Radiotherapy is frequently employed as part of the multimodal treatment of pelvic cancers. Despite recent advances in irradiation techniques, acute and late- onset radiation-induced gastrointestinal toxicity, also known as pelvic radiation disease, is still being frequently reported. This review provides an up-to-date summary on medical and endoscopic approaches that have been evaluated with treating intent, focusing on the best available evidence, primarily randomized controlled studies.