Bagul N, Ganjre A, Goryawala S, Kathariya R, Dusane S. Dynamic role of myofibroblasts in oral lesions. World J Clin Oncol 2015; 6(6): 264-271 [PMID: 26677439 DOI: 10.5306/wjco.v6.i6.264]
Corresponding Author of This Article
Dr. Rahul Kathariya, MDS, PhD, Department of Periodontology and Oral Implantology, Dr. D.Y Patil Dental College and Hospital, Dr. D. Y Patil Vidyapeeth, Sant Tukaram Nagar, Pimpri, Pune 411018, India. rkathariya@gmail.com
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Dec 10, 2015; 6(6): 264-271 Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.264
Dynamic role of myofibroblasts in oral lesions
Neeta Bagul, Anjali Ganjre, SN Goryawala, Rahul Kathariya, Shrikant Dusane
Neeta Bagul, Anjali Ganjre, Department of Oral Pathology and Microbiology, Dr. D.Y Patil Dental College and Hospital, Dr. D. Y Patil Vidyapeeth, Pune 411018, India
SN Goryawala, Department of Dentistry, GMERS Medical College, Vadodara 390021, Gujrat
Rahul Kathariya, Department of Periodontology and Oral Implantology, Dr. D.Y Patil Dental College and Hospital, Dr. D. Y Patil Vidyapeeth, Pune 411018, India
Shrikant Dusane, Department of Oral and Maxillofacial Surgery, Sinhgad Dental College and Hospital, Pune 411041, India
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: The author confirm that the manuscript is original and has not been published elsewhere. Nor is it sent to any other journals for consideration. In addition, the authors report no conflict of interest, and the manuscript in its submitted form has been read and approved by all authors.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Rahul Kathariya, MDS, PhD, Department of Periodontology and Oral Implantology, Dr. D.Y Patil Dental College and Hospital, Dr. D. Y Patil Vidyapeeth, Sant Tukaram Nagar, Pimpri, Pune 411018, India. rkathariya@gmail.com
Telephone: +91-89-83370741
Received: April 10, 2015 Peer-review started: April 11, 2015 First decision: June 4, 2015 Revised: August 4, 2015 Accepted: September 7, 2015 Article in press: September 8, 2015 Published online: December 10, 2015
Core Tip
Core tip: Myofibroblast (MFs) are spindle-shaped cells consisting α-smooth muscle actin myofilament. They have a multicellular origin. MFs of the oral cavity have more contractile ability than dermal fibroblasts in physiologic wound healing. Recently, carcinoma-associated fibroblasts (CAFs) have received considerable attention because of their role in carcinogenesis. Mainly, transforming growth factor-β released from oral cancer cells is responsible for transforming fibroblasts into CAFs, which leads to tumour progression. However, the role of MFs in oral leukoplakia and oral submucous fibrosis is not completely understood. Understanding the implications of therapeutic approaches for the transdifferentiation of fibroblasts into MFs at different stages of carcinogenesis will facilitate in developing a treatment plan.
