Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 10, 2015; 6(6): 237-251
Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.237
Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.237
Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract
Tsunenori Kondo, Toshio Takagi, Kazunari Tanabe, Department of Urology, Tokyo Women’s Medical University, Tokyo 162-8666, Japan
Author contributions: Kondo T wrote the paper; Kondo T and Takagi T collected the data; Tanabe K supervised the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tsunenori Kondo, MD, PhD, Department of Urology, Tokyo Women’s Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. tkondo@kc.twmu.ac.jp
Telephone: +81-3-33538111 Fax: +81-3-33560293
Received: May 28, 2015
Peer-review started: June 1, 2015
First decision: August 4, 2015
Revised: August 14, 2015
Accepted: October 1, 2015
Article in press: October 8, 2015
Published online: December 10, 2015
Peer-review started: June 1, 2015
First decision: August 4, 2015
Revised: August 14, 2015
Accepted: October 1, 2015
Article in press: October 8, 2015
Published online: December 10, 2015
Core Tip
Core tip: The role of lymphadenectomy in urothelial carcinoma of the upper urinary tract had examined. A prospective study showed that anatomical template-based lymphadenectomy significantly improves patient survival in tumors of the renal pelvis. This benefit is demonstrated more clearly for patients with pT2 tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy, which is likely to be associated with improved patient survival. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease. Further studies are warranted to collect the evidence to support lymphadenectomy.