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World J Clin Oncol. Aug 10, 2014; 5(3): 520-528
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.520
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.520
Green tea compounds in breast cancer prevention and treatment
Min-Jing Li, Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, Shandong Province, China
Yan-Cun Yin, Yang-Fu Jiang, State Key Laboratory of Biotherapy, Section of Oncogene, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Jiao Wang, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan Province, China
Author contributions: Li MJ and Jiang YF designed the manuscript; Li MJ, Yin YC, Wang J and Jiang YF wrote the manuscript.
Supported by National Natural Science Foundation of China, No. 81001587
Correspondence to: Yang-Fu Jiang, Professor, State Key Laboratory of Biotherapy, Section of Oncogene, West China Hospital, Sichuan University, Wangjiang Rd 29, Chengdu 610041, Sichuan Province, China. jyangfu@scu.edu.cn
Telephone: +86-21-85164044 Fax: +86-21-85164045
Received: December 25, 2013
Revised: February 12, 2014
Accepted: April 9, 2014
Published online: August 10, 2014
Revised: February 12, 2014
Accepted: April 9, 2014
Published online: August 10, 2014
Core Tip
Core tip: Green tea components, especially epigallocatechin-3-gallate, possess anti-breast cancer effects. However, their effects on breast cancer prevention and therapy are still inconclusive. The anti-tumor mechanisms of green tea remain elusive. This review focuses on epidemiological and animal studies on green tea components against tumorigenesis, as well as possible mechanisms involved.