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World J Clin Oncol. Aug 10, 2014; 5(3): 359-373
Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.359
Main controversies in breast cancer
Stephane Zervoudis, George Iatrakis, Eirini Tomara, Anastasia Bothou, George Papadopoulos, George Tsakiris
Stephane Zervoudis, George Iatrakis, George Papadopoulos, George Tsakiris, Rea Hospital, 17564 Athens, Greece
Stephane Zervoudis, George Iatrakis, Eirini Tomara, Anastasia Bothou, George Tsakiris, Technological University of Athens, 12210 Athens, Greece
Author contributions: Zervoudis S and Iatrakis G came up with the title and the format of the manuscript; Zervoudis S, Iatrakis G, Tomara E and Bothou A wrote the paper; Iatrakis G made the final corrections; Papadopoulos G and Tsakiris G help for the issues based on chemotherapy and radiotherapy consecutively.
Correspondence to: Dr. Stephane Zervoudis, Rea Hospital, 383-Suggrou Avenue, Palaio Faliro, 17564 Athens, Greece. szervoud@otenet.gr
Telephone: +69-44-308777 Fax: +30-210-8981178
Received: December 17, 2013
Revised: April 7, 2014
Accepted: May 13, 2014
Published online: August 10, 2014
Core Tip

Core tip: Taking into consideration the progress in diagnosis and treatment in the female breast cancer, it is inevitable that some controversies will come up in daily clinical practice. The aim of this review is to illustrate some of these conflicting issues and make them less “ambiguous”. Thus, this has been achieved in the issues of mammography, magnetic resonance imaging, fine needle aspiration and core biopsy, axillary dissection, internal mammary node sampling, accelerated partial breast irradiation, the sequence of chemoradiotherapy, negative margin width, while controversial are still remain the themes of tomosynthesis, 3D ultrasound, shear wave elastography, positron emission tomography-computed tomography (PET-CT), CT-scan and bone scintigraphy, hormonotherapy, bisphosphonates and sentinel lymph node biopsy.